The placement of prophylactic intra-abdominal drains has been common practice in abdominal operations including pancreatic surgery.
The PANDRA trial showed that the omission of drains following pancreatic head resection was non-inferior to intra-abdominal drainage in terms of postoperative reinterventions and superior in terms of clinically relevant pancreatic fistula rate and fistula-associated complications. The aim of the present PANDRA II trial is to evaluate the clinical outcome with versus without prophylactic drain placement after distal pancreatectomy.
In the control group at least one passive intra-abdominal drain is placed at the pancreatic resection margin.
In the experimental group pandra drains are placed. Secondary endpoints are in-hospital mortality and morbidity, including the rates of postoperative pancreatic fistula, chyle leak, postpancreatectomy hemorrhage, delayed gastric emptying, reinterventions and reoperations, surgical site infection, and abdominal fascia dehiscence. Moreover, length of hospital stay, duration of intensive care unit stay, and the rate of readmission after discharge from hospital up to day 90 after surgery are assessed.
Pandra 2: Imaginar, Crear, Dibujar (Coleccion P&E)
The results of the PANDRA II trial will help to evaluate the effect of an omission of prophylactic intraperitoneal drainage on the rate of complications after open or minimally invasive distal pancreatectomy. Registered on 6 March The placement of prophylactic intra-abdominal drains to reduce postoperative surgical complications has been common practice in abdominal surgery for decades.
Recent studies, however, have failed to show any benefit of routine drainage following many abdominal resections including hepatobiliary [ 12 ], gastric [ pandrablue eyed hottie ], and colorectal surgery [ 5pandra ]. These studies have shown that surgery can be performed safely without prophylactic drainage.